My thought is that Hyuuga Neji will defeat Uchiha Sasuke with no problem because with no jutsu Sasuke is useless and Neji`s Hand to Hand is way batter than Sasuke`s.
Even with CS2 it wouldn't be a cake walk. Neji has 360° vision with his Byakugan. But the unfortunate thing is that Sasuke is too hax therefore by default he'd win. Sasuke basically ruined the whole series... -_____-
well technacally sasuke and neji would be a good fight but sasuke has some advanteges that neji doesn't,neji has one hole in his 360 degree vision,and if neji can't touch sasuke theres no point in using the gentle fist,sasuke has plenty of jutsu,for one he has the chidori,the fire jutsus and chidori nigashi,do i have to mention that he has the curse mark including curse seal lv 2,plus in shippudden he has the sword of kusanagi,now on to neji's point of view,the byakugan is useful to stop chakra but he would have to continue to stay close to sasuke which is kinda impossible with sasuke being so fast,neji however is also fast but if sasuke gets out into some trees like kidomaru did againest neji i doubt neji would win
This happened on one of the games on the Gamecube and you could do a com vs. com match to see who would win at the highest difficulty. I think Sasuke would win though.
Ok my though is still Hyuuga Neji will destroy Uchiha Sasuke but how about this the Hyuuga Clan vs The Uchiha Clan and I am a fan of both clans and I say the Hyuuga`s would destroy them.